A convenient approach by using poly‐(HEMA‐co‐NIPAM)/Cu2+ solution sol–gel transition for wound protection and healing. Issue 1 (5th July 2020)

• Record Type: Journal Article
• Authors: Wang, Yansong; Chu, Xin; Sun, Yu; Teng, Peng; Xia, Tianzhi; Chen, Yisheng
• Is Part Of: Journal of biomedical materials research. Volume 109:Issue 1(2021)
• Page Start: 50
• Page End: 59
• Publication Date: 2020-07-05
• Subjects: angiogenesis -- antibacterial -- temperature‐sensitive -- wound healing; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.b.34679
• Languages: English
• ISSNs: 1552-4973

Abstract

Abstract: Rapid and convenient wound healing is crucial for reducing potential post‐traumatic wound complications. In this study, a temperature‐sensitive polymer of poly‐(HEMA‐co‐NIPAM) (PHN) was synthesized by free‐radical polymerization, in which the solution quickly underwent a sol–gel transition above 29°C, thus responding to a typical body temperature and facilitating wound sealing. PHN solution incorporated with copper ions (PHN‐Cu) not only exhibited excellent antibacterial properties, but also expedited wound closure and facilitated tissue angiogenesis. The in vivo and in vitro experiments showed that the PHN‐Cu had a higher wound closure rate and demonstrated an ability to promote skin tissue angiogenesis. Such a versatile, convenient aqueous solution could enable nonprofessionals to promptly treat wounds in a short time after injury, thus providing suitable conditions for later treatment, and can be used as a convenient method to clean wounds.