Application of MWCNT/Ag‐Pt Nanocomposite Modified GCE for the Detection of Nevirapine in Pharmaceutical Formulation and Biological Samples. Issue 12 (27th October 2020)

• Record Type: Journal Article
• Authors: Okumu, Fredrick O.; Silwana, Bongiwe; Matoetoe, Mangaka C.
• Is Part Of: Electroanalysis. Volume 32:Issue 12(2020)
• Page Start: 3000
• Page End: 3008
• Publication Date: 2020-10-27
• Subjects: electrochemical -- bimetallic -- nanoparticles -- nevirapine -- silver -- platinum; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.202060374
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: A study of nanosensor comprising of a glassy carbon electrode modified with a composite of multiwall carbon nanotube (MWCNT) and bimetallic (Ag‐PtNPs) for the determination of Nevirapine. The GCE/MWCNT/Ag‐PtNPs sensor had remarkable electrocatalytic properties with enhanced response towards Nevirapine under optimized conditions. The platform electrochemical characterisation in 0.01 M NaOH solution, with cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV) is detailed. The limit of the detection (LOD) was 0.021 μM. The nanosensor was validated for real sample study using spiked pharmaceutical dose form, milk and urine samples, which showed acceptable recoveries (90‐ 112 %), good precision (RSD=3.3 %, N=3), reproducibility (RSD=4.3 %) and excellent selectivity towards Nevirapine from studied interferents. Abstract :