Influence of age on response to controlled ovarian stimulation in women with low levels of serum anti-Müllerian hormone. (1st December 2020)

• Record Type: Journal Article
• Authors: Massarotti, Claudia; La Pica, Valentina; Sozzi, Fausta; Scaruffi, Paola; Remorgida, Valentino; Anserini, Paola
• Is Part Of: Gynecological endocrinology. Volume 36:Number 12(2020)
• Page Start: 1074
• Page End: 1078
• Publication Date: 2020-12-01
• Subjects: IVF -- AntiMullerian hormone (AMH) -- ovarian reserve -- controlled ovarian stimulation; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2020.1737668
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: This study aims at detecting and evaluating differences in quantitative response to controlled ovarian stimulation (COS) with high doses of gonadotropins in women with low serum anti-Müllerian hormone (AMH). About 369 first cycles in a real-life scenario in women between 21 and 43 years old and with AMH ≤0.9 ng/ml were analyzed. Older women had a significantly worse outcome with respect to young women, not only qualitatively, but also in terms of quantitative ovarian response to COS [odd ratio (OR) to obtain at least three MII oocytes with each increasing year of female age: 0.89, 95% CI: 0.85 − 0.94; p < .001]. This study endorses that age is a significant factor when counseling patients with low AMH. AMH levels per se are not a reason to exclude patients from a COS treatment, since pregnancy and live birth can be achieved, especially in younger patients. However, with an AMH equally low, the ovarian response worsens with age, making questionable the effectiveness of a stimulation with high-dose gonadotropins in the older subgroup.