Development of potent inhibitors for strigolactone receptor DWARF 14. Issue 94 (16th November 2020)

• Record Type: Journal Article
• Authors: Yoshimura, Masahiko; Kim, Sojung F.; Takise, Ryosuke; Kusano, Shuhei; Nakamura, Sakuya; Izumi, Masanori; Yagi, Akiko; Itami, Kenichiro; Hagihara, Shinya
• Is Part Of: Chemical communications. Volume 56:Issue 94(2020)
• Page Start: 14917
• Page End: 14919
• Publication Date: 2020-11-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc01989e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Strigolactones (SLs) are plant hormones that suppress shoot branching through perception by their receptor protein DWARF 14 (D14). Based on the binding model of DL1, a small-molecule D14 inhibitor, more potent compounds were developed. Abstract : Strigolactones (SLs) are plant hormones that suppress shoot branching through perception by their receptor protein DWARF 14 (D14). The artificial regulation of SL signaling has been considered a potent agricultural technique because plant architecture is strongly related to crop yield. In this communication, we describe the development of a small-molecule D14 inhibitor that functions at sub-micromolar levels. This potent inhibitor may be a lead compound for a first-in-class plant growth regulator.