A conformational tweak for enhanced cellular internalization, photobleaching resistance and prolonged imaging efficacy. Issue 94 (11th November 2020)

• Record Type: Journal Article
• Authors: Meher, Niranjan; Bidkar, Anil Parsram; Barman, Debasish; Ghosh, Siddhartha Sankar; Iyer, Parameswar Krishnan
• Is Part Of: Chemical communications. Volume 56:Issue 94(2020)
• Page Start: 14861
• Page End: 14864
• Publication Date: 2020-11-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc05557c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A simple strategy of conformational manipulation has been unveiled to fine-tune the photophysical and supramolecular self-assembly properties of small molecular systems, which subsequently regulates their biological activities. Abstract : A strategy of conformational tweaking regulates the condensed state behavior of naphthalimide skeletal isomers (NSIs) and enhances their photophysical properties, cellular uptake and prolonged imaging capability. This salient approach results in a large Stokes shift (>120 nm), rapid cellular internalization, photobleaching resistance, and efficient bioimaging of the ribbon-like nano-assembly superior to that of its electronically similar micro-flower isomer.