To be more precise: the role of intracellular trafficking in development and pattern formation. (11th September 2020)

• Record Type: Journal Article
• Authors: York, Harrison M.; Coyle, Joanne; Arumugam, Senthil
• Is Part Of: Biochemical Society transactions. Volume 48:Number 5(2020)
• Page Start: 2051
• Page End: 2066
• Publication Date: 2020-09-11
• Subjects: developmental biology -- endosome -- signalling -- trafficking; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20200223
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Living cells interpret a variety of signals in different contexts to elucidate functional responses. While the understanding of signalling molecules, their respective receptors and response at the gene transcription level have been relatively well-explored, how exactly does a single cell interpret a plethora of time-varying signals? Furthermore, how their subsequent responses at the single cell level manifest in the larger context of a developing tissue is unknown. At the same time, the biophysics and chemistry of how receptors are trafficked through the complex dynamic transport network between the plasma membrane–endosome–lysosome–Golgi–endoplasmic reticulum are much more well-studied. How the intracellular organisation of the cell and inter-organellar contacts aid in orchestrating trafficking, as well as signal interpretation and modulation by the cells are beginning to be uncovered. In this review, we highlight the significant developments that have strived to integrate endosomal trafficking, signal interpretation in the context of developmental biology and relevant open questions with a few chosen examples. Furthermore, we will discuss the imaging technologies that have been developed in the recent past that have the potential to tremendously accelerate knowledge gain in this direction while shedding light on some of the many challenges.