Association about dietary vitamin C intake on the risk of ovarian cancer: a meta-analysis. Issue 8 (7th August 2020)

• Record Type: Journal Article
• Authors: Long, Yuhang; Fei, Hui; Xu, Sumei; Wen, Jianzhen; Ye, Lihua; Su, Zhaojuan
• Is Part Of: Bioscience reports. Volume 40:Issue 8(2020)
• Publication Date: 2020-08-07
• Subjects: Dietary -- Meta-analysis -- Ovarian cancer -- Vitamin C; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20192385
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract: Changes in dietary vitamin C intake have been related to the risks of various cancers. However, the association between dietary vitamin C intake and the risk of ovarian cancer has not been fully determined. A meta-analysis was performed to evaluate the relationship between vitamin C intake and ovarian cancer risk. Observational studies that evaluated the association between vitamin C intake and ovarian cancer risk were identified via systematic search of PubMed and Embase databases. A random-effect model was used to combine relative risk (RR) with corresponding 95% confidence intervals (CIs). As a result, 16 studies (5 cohort studies and 11 case–control studies) with 4553 cases and 439, 741 participants were included. Pooled results showed that dietary vitamin C intake had non-significant association on the risk of ovarian cancer (RR = 0.95, 95%CI = 0.81–1.11, I 2 = 52.1%, P for heterogeneity = 0.008). Subgroup analyses according to characteristics including geographic location and study design showed consistent results with the overall result. In summary, findings from the present study indicated that dietary vitamin C intake is not associated with the risk of ovarian cancer.