Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception. Issue 2 (14th May 2020)

• Record Type: Journal Article
• Authors: Anamthathmakula, Prashanth; Winuthayanon, Wipawee
• Is Part Of: Biology of reproduction. Volume 103:Issue 2(2020)
• Page Start: 411
• Page End: 426
• Publication Date: 2020-05-14
• Subjects: semen liquefaction -- semenogelins -- kallikrein-related peptidase -- prostate-specific antigen -- sperm motility -- contraceptive -- fertility; Reproduction -- Periodicals; Biology; Reproduction; Reproduction; Electronic journals; Periodicals; Periodicals; 571.805
• DOI: 10.1093/biolre/ioaa075
• Languages: English
• ISSNs: 0006-3363

Abstract

Abstract: Semen liquefaction is a proteolytic process where a gel-like ejaculated semen becomes watery due to the enzymatic activity of prostate-derived serine proteases in the female reproductive tract. The liquefaction process is crucial for the sperm to gain their motility and successful transport to the fertilization site in Fallopian tubes (or oviducts in animals). Hyperviscous semen or failure in liquefaction is one of the causes of male infertility. Therefore, the biochemical inhibition of serine proteases in the female reproductive tract after ejaculation is a prime target for novel contraceptive development. Herein, we will discuss protein components in the ejaculates responsible for semen liquefaction and any developments of contraceptive methods in the past that involve the liquefaction process. Abstract : We propose inhibition of semen liquefaction has the potential to be developed as a non-hormonal contraceptive method.