Intra-abdominal hypertension as a trigger of "gut failure" in SARS-CoV-2 infection: Effect of open abdomen (OA) and negative pressure therapy (NPT) on respiratory and gastrointestinal (GI) function. (November 2020)

• Record Type: Journal Article
• Authors: Di Grezia, Marta; Fransvea, Pietro; Santullo, Francesco; Tirelli, Flavio; Fico, Valeria; Mirco, Paolo; Cozza, Valerio; La Greca, Antonio; Sganga, Gabriele
• Is Part Of: Medical hypotheses. Volume 144(2020)
• Publication Date: 2020-11
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Medicine; Periodicals; 610
• DOI: 10.1016/j.mehy.2020.109954
• Languages: English
• ISSNs: 0306-9877

Abstract

Abstract: COVID-19 gastrointestinal manifestations could be attributed to SARS-CoV-2-induced small vessel thrombosis. OA with NPT treatment may have a role in optimization of bowel microcirculation and in the reduction of the endothelial and the systemic cytokine-related damage, improving also respiratory function.