Intelligence quotient level and treatment of obsessive-compulsive disorders: Meta-analyses. (November 2020)

• Record Type: Journal Article
• Authors: Hu, Lidan; Hao, Youguo; Liu, Shudong; Kang, Hongying; Qin, Li; Zeng, Zhen; Abdelrahim, Mohamed E.A.; Tan, Youguo
• Is Part Of: Medical hypotheses. Volume 144(2020)
• Publication Date: 2020-11
• Subjects: OCD Obsessive-compulsive disorder -- IQ intelligence quotient -- SSRIs selective-serotonin reuptake-inhibitors -- CBT cognitive-behavioral therapy -- OR Odd ratio -- CIs 95% confidence intervals -- DSM-5 diagnostic and statistical manual of mental disorders; Intelligence quotient -- Obsessive-compulsive disorders -- Selective-serotonin reuptake-inhibitors -- Cognitive-behavioral therapy; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Medicine; Periodicals; 610
• DOI: 10.1016/j.mehy.2020.109995
• Languages: English
• ISSNs: 0306-9877

Abstract

Abstract: Background: Obsessive-compulsive disorder (OCD) is a highly heterogeneous mental disorder that could affect mental capacity and requires different treatment methods. The purpose of this meta -analysis study was to evaluate the OCD subjects' intelligence quotient (IQ) and the effect of different treatments on OCD. Methods: Through a systematic literature search up to December-2019, 108-studies were identified, with 8049-subjects with 6719-OCD subjects. The studies identified were 45 reporting IQs in OCD and 38 reporting comparisons between selective-serotonin reuptake-inhibitors (SSRIs) to placebo in the treatment of OCD, 9 reporting comparison between SSRIs to each other, 8 reporting comparison between cognitive-behavioral therapy (CBT) to placebo and 8 reporting comparison between CBT to SSRIs. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated comparison was made according to the study content using a continuous method with a random or fixed-effects model. Results: Subjects with OCD had significantly lower IQ (OR, −3.74; 95% CI, −4.83 to −2.64) than normal subjects. SSRIs (OR, −4.09; 95% CI, −4.87 to −3.30) and CBT (OR, −15.13; 95% CI, −19.27 to −10.99) had better effect than placebo in OCD treatment. No significant difference were found between different types of SSRIs (OR, -0.42; 95% CI, −1.32–0.49) or between CBT and SSRIs (OR, −1.99; 95% CI, −4.20 to 0.22) with non-significant better values favoring CBT. Conclusions: The IQ of the OCD subjects was significantly lower than in normal subjects. The SSRIs and the CBT had a significant effect on treating OCD. Different SSRIs are similar in their effect on OCD. More studies are required to separate between CBT and SSRIs' insignificant differences.