Cardiotoxicity of doxorubicin-based cancer treatment: What is the protective cognition that phytochemicals provide us?. (October 2020)

• Record Type: Journal Article
• Authors: Liu, Cun; Ma, Xiaoran; Zhuang, Jing; Liu, Lijuan; Sun, Changgang
• Is Part Of: Pharmacological research. Volume 160(2020)
• Publication Date: 2020-10
• Subjects: DOX doxorubicin -- FDA Food and Drug Administration -- cGMP cyclic guanosine monophosphate -- MgIG magnesium isoglycyrrhizinate -- AChE acetylcholinesterase -- AKT Protein kinase B -- ALT alanine aminotransferase -- AMPK adenosine 5′-monophosphate (AMP)-activated protein kinase -- ARE antioxidant response element -- AST Aspartate aminotransferase -- ATF6 activating transcription factor 6 -- CAT catalase -- CK creatine kinase -- CK-MB creatine kinase MB -- COX-2 cyclooxygenase-2 -- CPK creatine phosphokinase -- cTnI cardiac troponin I -- CYP cytochrome P450 proteins -- ECG electrocardiogram -- eNOS endothelial nitric oxide synthase -- ER endoplasmic reticulum -- ERK extracellular signal-regulated kinase -- GCLM glutamate-cysteine ligase modifier subunit -- GPX glutathione peroxidase -- GR glutathione reductase -- GRP78 glucose-regulated protein 78 -- GSH glutathione -- GSH-Px glutathine peroxidase -- GSSG oxidized glutathione -- GST glutathione s-transferase -- HO-1 heme oxygenase-1 -- HSF heat shock transcription factor -- IL-1β interleukin-1β -- IL-6 interleukin-6 -- iNOS inducible nitric oxide synthase -- IRE1 inositol-requiring enzyme 1 -- JNK c-Jun N-terminal kinase -- LDH lactate dehydrogenase -- LPO lipid peroxidation -- LVEF left ventricular ejection fraction -- LVFS left ventricular fractional shortening -- MAPK mitogen-activated protein kinase -- MDA malondialdehyde -- NADH nicotinamide adenine dinucleotide -- NF-κB nuclear factor-κB -- NLRP3 NOD-like receptor family pyrin domain-containing 3 -- NO nitric oxide -- NQO1 NAD(P)H quinone oxidoreductase 1 -- OXPHOS oxidative phosphorylation -- PARP poly ADP-ribose polymerase -- PGC1α peroxlsome proliferator-activated receptor-γ coactlvator-1α -- PI3K phosphoinositide 3-kinase -- PPARγ peroxisome proliferator-activated receptor γ -- PTEN phosphate and tension homology deleted on chromsome ten -- ROS reactive oxygen species -- S6K1 S6 kinase 1 -- SGOT serum glutamic oxaloacetic transaminase -- SGPT serum glutamic pyruvic transaminase -- SIRT1 silent information regulator 1 -- SPHK1 sphingosine kinase 1 -- TAO total antioxidant -- TC total cholesterol -- TG triglyceride -- TGF-β transforming growth factor-β -- TNF tumour necrosis factor -- TRPC transient receptor potential canonical -- ULK1 unc-51 like autophagy activating kinase 1 -- USP7 ubiquitin specific peptidase 7; Doxorubicin -- Cardiotoxicity -- Phytochemicals; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2020.105062
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Doxorubicin (DOX) continues to attract the interest of preclinical and clinical investigations despite its longer-than-50-year record of longevity. The clinical application of DOX can be regarded as a sort of double-edged sword. On one hand, anthracyclines play an indisputable key role in the treatment of tumors; on the other hand, their chronic administration leads to cardiomyopathy and congestive heart failure, which is usually refractory to common medications. Finding the ideal cardioprotective agents has always been the focus of oncologists and cardiologists. Researchers put a lot of energy into phytochemicals because they are often in line with the expected standards, that is, to improve DOX-induced cardiotoxicity without compromising the clinical efficacy or to even produce synergy. We summarized the previous efforts, briefly outlined the mechanism of DOX cardiotoxicity, and focused on exploring the protective effects and potential mechanisms of all phytochemical types that have been investigated under DOX-induced cardiotoxicity. Phytochemicals have been found to be potential cardioprotective agents with universal safety and effectiveness. As a resource repository of pharmacophores, phytochemicals deserve to be utilized as drug templates for further development and research in combating DOX-induced cardiotoxicity.