Inflammatory Response: USP38 Couples Histone Ubiquitination and Methylation via KDM5B to Resolve Inflammation (Adv. Sci. 22/2020). Issue 22 (19th November 2020)
- Record Type:
- Journal Article
- Title:
- Inflammatory Response: USP38 Couples Histone Ubiquitination and Methylation via KDM5B to Resolve Inflammation (Adv. Sci. 22/2020). Issue 22 (19th November 2020)
- Main Title:
- Inflammatory Response: USP38 Couples Histone Ubiquitination and Methylation via KDM5B to Resolve Inflammation (Adv. Sci. 22/2020)
- Authors:
- Zhao, Zhiyao
Su, Zexiong
Liang, Puping
Liu, Di
Yang, Shuai
Wu, Yaoxing
Ma, Ling
Feng, Junyan
Zhang, Xiya
Wu, Chenglei
Huang, Junjiu
Cui, Jun - Abstract:
- Abstract : In article number 2002680, Jun Cui and co‐workers identify a new histone modifier‐USP38, that modulates histone ubiquitination and methylation to resolve inflammatory response. USP38 acts as a "Safety Machine" which shuts down the inflammation by de‐ubiquitinating histone H2B and stabilizes KDM5B to de‐methylate H3K4, which blocks the transcription of pro‐inflammatory genes. The USP38‐KDM5B complex might be a potential clinical target for therapy against inflammatory diseases.
- Is Part Of:
- Advanced science. Volume 7:Issue 22(2020)
- Journal:
- Advanced science
- Issue:
- Volume 7:Issue 22(2020)
- Issue Display:
- Volume 7, Issue 22 (2020)
- Year:
- 2020
- Volume:
- 7
- Issue:
- 22
- Issue Sort Value:
- 2020-0007-0022-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2020-11-19
- Subjects:
- Science -- Periodicals
505 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/advs.202070122 ↗
- Languages:
- English
- ISSNs:
- 2198-3844
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 14862.xml