Unsymmetrical Disulfides Synthesis via Cs2CO3‐Catalyzed Three‐Component Reaction in Water. Issue 22 (17th September 2020)

• Record Type: Journal Article
• Authors: Wang, Dungai; Gao, Yuanji; Tong, Yunli; Xiong, Mingteng; Liang, Xiao; Zhu, Heping; Pan, Yuanjiang
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 22(2020)
• Page Start: 4991
• Page End: 4995
• Publication Date: 2020-09-17
• Subjects: Three-component reaction -- Nucleophilic substitution -- Water; Green Chemistry -- Synthetic methods; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000851
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An unsymmetrical disulfides synthesis by Cs2 CO3 ‐catalyzed three‐component coupling reaction of thioacetate, sodium thiosulfate, and benzyl halide in water is described. The safe, stable, and non‐toxic Na2 S2 O3 was invoked as the sulfur‐source, successfully avoiding the odor generation in the process of S−S bond formation. A wide range of substrate suitability and appropriate functional group tolerance were observed for the transformation. Notably, the approach reported here was compatible with various biomolecules including glucose, coumarin, and quinolinone. Abstract :