Multidimensional Anisotropic Architectures on Polymeric Microparticles. Issue 46 (20th October 2020)

• Record Type: Journal Article
• Authors: Agusil, Juan Pablo; Arjona, María Isabel; Duch, Marta; Fusté, Naüm; Plaza, José A.
• Is Part Of: Small. Volume 16:Issue 46(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-20
• Subjects: anisotropy -- barcoding -- molecular multiplexing -- polymer pen lithography -- polymeric microparticles; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202004691
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Next generation life science technologies will require the integration of building blocks with tunable physical and chemical architectures at the microscale. A central issue is to govern the multidimensional anisotropic space that defines these microparticle attributes. However, this control is limited to one or few dimensions due to profound fabrication tradeoffs, a problem that is exacerbated by miniaturization. Here, a vast number of anisotropic dimensions are integrated combining SU‐8 photolithography with (bio)chemical modifications via soft‐lithography. Microparticles in a 15‐D anisotropic space are demonstrated, covering branching, faceting, fiducial, topography, size, aspect ratio, stiffness, (bio)molecular and quantum dot printing, top/bottom surface coverage, and quasi‐ 0D, 1D, 2D, and 3D surface patterning. The strategy permits controlled miniaturization on physical dimensions below 1 µm and molecular patterns below 1 µm 2 . By combining building blocks, anisotropic microparticles detect pH changes, form the basis for a DNA‐assay recognition platform, and obtain an extraordinary volumetric barcoding density up to 1093 codes µm −3 in a 3 × 12 × 0.5 µm 3 volume. Abstract : A multidimensional anisotropic framework is established to design next‐generation suspended miniaturized systems. Here, SU‐8 microparticles are fabricated within a 15D anisotropic space. Their physical attributes are constructed via photolithography. Subsequently, the microparticles are patterned with soft‐lithography forming (bio)molecular and nanoparticle motifs, consolidating pattern anisotropies while endowing distinct chemical and surface coverage signatures for bespoke multiplexing, Janus, and barcoding applications.