Proliferative nodule resembling angiomatoid Spitz tumor with degenerative atypia arising within a giant congenital nevus. (30th September 2020)

• Record Type: Journal Article
• Authors: Braunberger, Taylor L.; Adelman, Madeline; Shwayder, Tor A.; Clarke, Loren E.; Friedman, Ben J.
• Is Part Of: Journal of cutaneous pathology. Volume 47:Number 12(2020)
• Page Start: 1200
• Page End: 1204
• Publication Date: 2020-09-30
• Subjects: ancient nevus -- angiomatoid Spitz -- congenital melanocytic nevi -- malignant melanoma -- proliferative nodule; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.13840
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract: Proliferative nodules arising within congenital melanocytic nevi often present a diagnostic challenge given a close resemblance to melanoma. Several morphologic variants have been characterized. In difficult cases, ancillary molecular tests can be used to better exclude the possibility of malignant degeneration. Herein, we report a case of an unusual proliferative nodule with overlapping features of angiomatoid Spitz tumor and ancient melanocytic nevus, which demonstrated normal findings on both chromosomal microarray and a gene expression profiling assay.