Formal [3+2] Annulation of Copper‐Allenylidenes with 3‐Oxo‐3‐Arylpropanenitriles: Synthesis of Tetrasubstituted Furans. Issue 22 (1st October 2020)

• Record Type: Journal Article
• Authors: Zhong, De; Jiang, Feng; Shen, Siyong; Wang, Lan; Wang, Wei; Wu, Yongjun; Xiao, Yumei; Guo, Hongchao
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 22(2020)
• Page Start: 5026
• Page End: 5030
• Publication Date: 2020-10-01
• Subjects: copper-allenylidene -- annulation -- decarboxylative -- ethynyl benzoxazinanone -- furan; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000929
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The copper‐catalyzed decarboxylative [3+2] annulation of ethynyl benzoxazinanones with 3‐oxo‐3‐arylpropanenitriles has been developed, producing tetrasubstituted furan derivatives in moderate to high yield. This reaction was generally compatible with a wide range of substrates. Notably, the intermediate copper‐allenylidenes worked as a C2 synthon in the cycloaddition reaction. Abstract :