Agaricus bisporus-derived β-glucan enter macrophages and adipocytes by CD36 receptor. Issue 22 (16th November 2020)

• Record Type: Journal Article
• Authors: Li, Xiumin; Zhang, Xiufen; Pang, Liang; Yao, Liyun; ShangGuan, Zhaoshui; Pan, Yutian
• Is Part Of: Natural product research. Volume 34:Issue 22(2020)
• Page Start: 3253
• Page End: 3256
• Publication Date: 2020-11-16
• Subjects: Agaricus bisporus-derived β-glucan -- Raw 264.7 macrophages -- 3T3-L1 adipocytes -- CD36 -- imaging flow cytometry; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1556654
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: β-glucans are a heterogeneous group of natural polysaccharides. They are ubiquitously found in bacterial or fungal cell walls, cereals, seaweed, and mushrooms. The beneficial role of β-glucan in tumor, insulin resistance, dyslipidemia, hypertension, and obesity is being continuously documented. Ample evidence showed that β-glucan could act on several receptors, such as Dectin, complement receptor (CR3), TLR-2, 4, 6 and scavenger. Based on the above, we wanted to explore whether agaricus bisporus -derived β-glucan acted on these receptors on Raw 264.7 macrophages and 3T3-L1 adipocytes. Graphical Abstract: