Antileishmanial and cytotoxic activities of a new limonoid and a new phenyl alkene from the stem bark of Trichilia gilgiana (Meliaceae). Issue 22 (16th November 2020)

• Record Type: Journal Article
• Authors: Kowa, Theodora K.; Tchokouaha, Lauve R. Y.; Cieckiewicz, Ewa; Philips, Trudy Janice; Dotse, Eunice; Wabo, Hippolyte K.; Tchinda, Alembert T.; Tane, Pierre; Frédérich, Michel
• Is Part Of: Natural product research. Volume 34:Issue 22(2020)
• Page Start: 3182
• Page End: 3188
• Publication Date: 2020-11-16
• Subjects: Trichilia gilgiana -- Meliaceae -- limonoid -- phenyl alkene -- antileishmanial activity -- Leishmania donovani -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1553879
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new limonoid, trigilgianin (1 ), one new phenyl alkene, epoxy gilgialkene (2 ), together with five known compounds: scopoletin (3 ), sitosteryl-6'- O -undecanoate- β -D-glucoside (4 ), sitosteryl- O - β -D-glucopyranoside (5 ), cinchonain A (6 ) and cinchonain B (7 ) were isolated from the stem bark of Trichilia gilgiana Harms. (Meliaceae). All compounds were isolated for the first time from this species. The structures were elucidated on the basis of spectral studies and by comparison of these data with those from the literature. Compounds 1, 2, 3, 6 and 7 were tested for in vitro antileishmanial activity against visceral leishmaniasis parasite Leishmania donovani and cytotoxicity against macrophage RAW 264.7 cell line. Compounds 1 and 3 showed the highest antileishmanial activity (IC50 values of 6.044 and 6.804 µg/mL, respectively) with low cytotoxicity (CC50 values of >200 and 47.47 µg/mL, respectively), while compound 2 was moderately active on L. donovani promastigotes (IC50 56.81 µg/mL). Graphical Abstract: