An efficient and easily-accessible ligand for Cu(i)-catalyzed azide–alkyne cycloaddition bioconjugation. Issue 92 (3rd November 2020)

• Record Type: Journal Article
• Authors: Guo, Yuan-Yang; Zhang, Bo; Wang, Luying; Huang, Shenlong; Wang, Shilei; You, Yanbo; Zhu, Gongming; Zhu, Anlian; Geng, Mingwei; Li, Lingjun
• Is Part Of: Chemical communications. Volume 56:Issue 92(2020)
• Page Start: 14401
• Page End: 14403
• Publication Date: 2020-11-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc06348g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel ligand (6) for copper-catalyzed azide–alkyne cycloaddition (CuAAC) in bioconjugation has been developed. Abstract : A novel ligand (6 ) for copper-catalyzed azide–alkyne cycloaddition (CuAAC) in bioconjugation has been developed. Both in vitro and in vivo experiments indicate that 6 is more efficient and less cytotoxic than the canonical CuAAC ligands. Besides, 6 is easily accessible and can be prepared at gram scale. Our study reveals that 6 might be an ideal CuAAC ligand for bioconjugations.