Selection of threose nucleic acid aptamers to block PD-1/PD-L1 interaction for cancer immunotherapy. Issue 93 (6th November 2020)

• Record Type: Journal Article
• Authors: Li, Xintong; Li, Zhe; Yu, Hanyang
• Is Part Of: Chemical communications. Volume 56:Issue 93(2020)
• Page Start: 14653
• Page End: 14656
• Publication Date: 2020-11-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc06032a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : In vitro selected threose nucleic acid (TNA) aptamers blocked PD-1/PD-L1 interaction and significantly inhibited tumour growth in xenograft mouse model. Abstract : Threose nucleic acid (TNA) aptamers were selected in vitro to bind PD-L1 protein and inhibit its interaction with PD-1. These biologically stable TNA aptamers bound target proteins with nanomolar affinities, and effectively blocked PD-1/PD-L1 interaction in vitro . After injection into a colon cancer xenograft mouse model, the TNA aptamer N5 was specifically accumulated at the tumour site, and significantly inhibited tumour growth in vivo .