A hitherto unknown stability of DNA basepairs. Issue 93 (5th November 2020)

• Record Type: Journal Article
• Authors: Davis, Daly; Sajeev, Y.
• Is Part Of: Chemical communications. Volume 56:Issue 93(2020)
• Page Start: 14625
• Page End: 14628
• Publication Date: 2020-11-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc06641a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The resonance capture of very low energy electrons (vLEEs) into the π* orbitals of nucleobases is a potential doorway to DNA damage. A rapid nonenzymatic structural response specific to the complementary basepairing is found to prevent direct damages. Abstract : The resonance capture of ubiquitous very low energy electrons (vLEEs) into the π* orbitals of nucleobases is a potential doorway to DNA damage. Our ab initio quantum chemical calculations reveal a possible protection function, which is specific to the complementary basepairing, against such vLEE induced DNA damage.