Synthesis of 3, 4, 5‐Trisubstituted Isoxazoles via the ANRORC Rearrangement. Issue 41 (20th October 2020)

• Record Type: Journal Article
• Authors: Kandula, Venu; Bandaru, Sravan K.; Balakrishna, C.; Chatterjee, Anindita; Yennam, Satyanarayana; Saunders, Graham C.; Behera, Manoranjan
• Is Part Of: European journal of organic chemistry. Issue 41(2020)
• Page Start: 6440
• Page End: 6446
• Publication Date: 2020-10-20
• Subjects: Cross‐coupling -- Heterocycles -- Oximes -- Sonogashira reaction -- Synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202001103
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A facile and versatile procedure for the synthesis of new functionalized derivatives of 3‐benzyl‐5‐(2‐hydroxyphenyl) isoxazole‐4‐carbaldehyde oxime has been described. The key step in the synthesis involves the ANRORC reaction of in‐situ generated 3‐(phenylethynyl)‐4H‐chromen‐4‐one with NH2 OH· HCl. Abstract : A facile and versatile procedure for the synthesis of functionalized 3‐benzyl‐5‐(2‐hydroxyphenyl) isoxazole‐4‐carbaldehyde oxime derivatives has been described. The key step in the synthesis involves the ANRORC reaction of in‐situ generated 3‐(phenylethynyl)‐4H‐chromen‐4‐one with NH2 OH· HCl.