Caspase 2 and p53 Reunited in Tumor Control. Issue 12 (December 2020)

• Record Type: Journal Article
• Authors: Petroni, Giulia; Vitale, Ilio; Galluzzi, Lorenzo
• Is Part Of: Trends in cell biology. Volume 30:Issue 12(2020)
• Page Start: 917
• Page End: 918
• Publication Date: 2020-12
• Subjects: CDK4/CDK6 inhibitors -- double-stand DNA breaks -- ionizing radiation -- MDM2 -- PIDD1 -- type I interferon; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2020.09.001
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : Recent findings (Tsabar et al . ) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.