Arterial spin labeling perfusion in neonates. Issue 5 (October 2020)

• Record Type: Journal Article
• Authors: Tortora, Domenico; Severino, Mariasavina; Rossi, Andrea
• Is Part Of: Seminars in fetal & neonatal medicine. Volume 25:Issue 5(2020)
• Publication Date: 2020-10
• Subjects: Newborn -- Perfusion -- Magnetic resonance imaging -- Arterial spin labeling; Neonatology -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.9201
• DOI: 10.1016/j.siny.2020.101130
• Languages: English
• ISSNs: 1744-165X

Abstract

Abstract: Abnormal brain perfusion is a key mechanism underlying neonatal brain injury. Understanding the mechanisms leading to brain perfusion changes in high-risk neonates and how these alterations may influence brain development is key to improve therapeutic strategies preventing brain injury and the neurodevelopmental outcome of these infants. To date, several studies demonstrated that Arterial Spin Labeling is a reliable tool to accurately and non-invasively analyze brain perfusion, facilitating the understanding of normal and pathological mechanisms underlying neonatal brain maturation and injury. This paper provides an overview of the normal pattern of brain perfusion on Arterial Spin Labeling in term and preterm neonates, and reviews perfusion abnormalities associated with common neonatal neurological disorders.