NCLX pumps up the heat. (December 2020)

• Record Type: Journal Article
• Authors: Pathak, Trayambak; Trebak, Mohamed
• Is Part Of: Cell calcium. Volume 92(2020)
• Publication Date: 2020-12
• Subjects: Mitochondrial Ca2+ signaling -- Mitochondrial Na+/Ca2+ exchanger NCLX -- Brown adipose tissue -- Non-shivering thermogenesis; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2020.102280
• Languages: English
• ISSNs: 0143-4160

Abstract

Highlights: NCLX activity is required for brown adipose tissue survival and thermogenesis. Stimulation of NCLX -/- brown adipocytes with norepinephrine causes mitochondrial Ca 2+ overload and apoptosis. NCLX -/- mice fail to maintain their body temperature in response to cold challenge. Abstract: Mitochondrial Ca 2+ signaling is a well-appreciated regulator of cell metabolism and energy production. A major function of mitochondria in brown adipose tissue (BAT) is thermogenesis. Assali et al. offer new insights into how the mitochondrial Ca 2+ extrusion mediator NCLX is crucial for BAT survival and thermogenesis.