Association between sleep duration and rupture of intracranial aneurysms: A single-center retrospective study. (November 2020)

• Record Type: Journal Article
• Authors: Zhang, Shuai; Shen, Yaoyao; Zhou, Chenguang; Zhu, Weisheng; Zhang, Fuqiang; Hu, Jie; Liu, Dong; Lv, Ming
• Is Part Of: Journal of clinical neuroscience. Volume 81(2020)
• Page Start: 252
• Page End: 258
• Publication Date: 2020-11
• Subjects: Intracranial aneurysm -- Rupture -- Risk -- Sleep duration -- Subarachnoid hemorrhage; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.09.060
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: The retrospective analysis of relationship between sleep duration and rupture of intracranial aneurysm (IAs) was carried out by us. Through this study, we found that the possibility of IAs rupture may increases when the sleep duration is ≤6 h. In addition, we reviewed the literature and analyzed the potential mechanisms for this correlation. Abstract: Objective: To assess the relationship between sleep duration and risk of rupture of intracranial aneurysms (IAs). Methods: According to our inclusion and exclusion criteria, 683 patients admitted to Beijing Tiantan Hospital were included in this study. There were 201 patients in the ruptured group and 482 patients in the unruptured group. Sleep duration was divided into three levels: ≥8 h (long), 6–8 h (normal), ≤6 h (short). Correlation between different sleep duration and rupture of IAs was evaluated by univariate and multivariate regression analysis. Results: The results of multivariate analysis demonstrated that there was a statistical difference between sleep duration of ≤6 h and sleep duration ≥8 h (OR = 1.76, CI = [1.08–2.87], p = 0.025). There was no statistically significant difference between the group with sleep duration of 6–8 h and sleep duration of ≥8 h (OR = 1.04, CI = [0.65–1.67], p = 0.857). Conclusion: Short sleep duration (≤6 h) may be related to the rupture of intracranial aneurysms. The reason for this correlation is not yet clear. We suspect that it may be caused by a series of physiological changes caused by reduced sleep.