Th17/Treg Imbalance and Atherosclerosis. (31st October 2020)

• Record Type: Journal Article
• Authors: He, Xin; Liang, Bo; Gu, Ning
• Other Names: Sakowicz Agata Academic Editor.
• Is Part Of: Disease markers. Volume 2020(2020)
• Publication Date: 2020-10-31
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2020/8821029
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Atherosclerosis is nowadays recognized as a chronic inflammatory disease of large arteries. In recent years, cellular and molecular biology studies on atherosclerosis confirmed that the occurrence and development are related to inflammation and autoimmunity. A variety of immune cells, cytokines, and transcription factors are involved in this process. Current studies found that T helper cell 17, regulatory T cells, and their cytokines play an important role in the development of atherosclerosis and vulnerable plaque rupture. Here, we provide a review of the up-to-date applications of T helper cell 17, regulatory T cells, cytokines, and their balance in the prognosis and therapy of atherosclerosis.