A Facile and Efficient Route for the Synthesis of Thiopyranoquinolines‐Fused Indole Moiety Using 2‐Chloroquinoline‐3‐carbaldehydes. Issue 40 (25th October 2019)

• Record Type: Journal Article
• Authors: Moghaddam, Firouz Matloubi; Moafi, Atiyeh; Ziadkhani, Ainaz; Daneshfar, Maryam; Razaghdoost, Narges
• Is Part Of: ChemistrySelect. Volume 4:Issue 40(2019)
• Page Start: 11683
• Page End: 11686
• Publication Date: 2019-10-25
• Subjects: Indole -- Thiopyranoquinolines -- Indoline-2-thione -- 2-Chloroquinoline-3-carbaldehydes -- Mild reaction conditions; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201902476
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The reaction of 2‐chloroquinoline‐3‐carbaldehydes with indoline‐2‐thione in ethanol provides a series of novel indolo[3′, 2′:5, 6]thiopyrano[2, 3‐b]quinoline derivatives. The desired products were obtained in short reaction time and high yields (69‐93%) under mild reaction conditions. Abstract : A series of novel thiopyranoquinolines fused indole moiety with potential bioactivities by the reaction of 2‐chloroquinoline‐3‐carbaldehydes and thiooxindol were synthesized and a joint experimental–computational UV‐Vis spectra of the product was investigated. Mild reaction conditions, good functional‐group tolerance, relatively short reaction time, easy workup, using ethanol as a green solvent and high yield of products are the advantages of this protocol. All the structures of products were identified with spectroscopy methods.