Impact of severe hypoglycaemia on psychological outcomes in adults with Type 2 diabetes: a systematic review. Issue 9 (4th August 2019)

• Record Type: Journal Article
• Authors: Hendrieckx, C.; Ivory, N.; Singh, H.; Frier, B. M.; Speight, J.
• Is Part Of: Diabetic medicine. Volume 36:Issue 9(2019)
• Page Start: 1082
• Page End: 1091
• Publication Date: 2019-08-04
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.14067
• Languages: English
• ISSNs: 0742-3071

Abstract

Abstract: Aim: Hypoglycaemia affects many people with Type 2 diabetes using insulin and other glucose‐lowering therapies. This systematic review examined the impact of severe hypoglycaemia (episodes requiring external assistance) on psychological outcomes (e.g. emotional well‐being, health status and quality of life) in adults with Type 2 diabetes. Methods: MEDLINE Complete, PsycINFO and CINAHL databases were searched for peer‐reviewed empirical studies, published in English, reporting the occurrence and severity of hypoglycaemia and its relationship with patient‐reported outcomes (PROs) in adults with Type 2 diabetes. Data were extracted from published reports and analysed. Results: Of 3756 potentially relevant abstracts, 29 studies met the inclusion criteria. Most reported cross‐sectional data and sample sizes varied widely ( N = 71 to 17 563). Although definitions of mild and severe hypoglycaemia were largely consistent between studies, additional non‐standard categorizations (e.g. moderate, very severe) were apparent and recall periods varied. Overall, severe hypoglycaemia was associated with increased fear of hypoglycaemia and decreased emotional well‐being, health status and diabetes‐specific quality of life. Effect sizes show that the association with fear of hypoglycaemia was stronger than with general health status. Conclusions: Notwithstanding the limitations of the empirical studies, these findings indicate that severe hypoglycaemia in adults with Type 2 diabetes (insulin‐ and non‐insulin‐treated) is associated with impaired psychological outcomes. Healthcare professionals should address the psychological impact of severe hypoglycaemia during clinical consultations, to support individuals to minimize exposure to, and the psychological consequences of, severe hypoglycaemia. What's new?: This is the first systematic review examining the psychological impact of severe hypoglycaemia in adults with Type 2 diabetes. For the most part, severe hypoglycaemia is associated with greater fear of hypoglycaemia, impaired general emotional well‐being and health status, and greater impairment of diabetes‐specific quality of life. The psychological impact of severe hypoglycaemia is not exclusive to those managing their diabetes with insulin. Health professionals need to actively assess and address the frequency and psychological impact of severe hypoglycaemia, minimize risk of exposure to severe hypoglycaemia, and provide support to the individual to deal with the psychological consequences.