Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516. Issue 3 (1st February 2018) - Lagu, Bharat
Graphical abstract: Comparison of gene regulation profiles, efficacy in thermal injury model and 14-day rat toxicity studies. Abstract: Compound 1 regulates significantly fewer genes than the PPARδ modulator, GW501516. Both compounds are efficacious in a thermal injury model of muscle regeneration. The restricted gene profile of 1 relative to GW501516 suggests that 1 may be pharmacoequivalent to GW501516 with fewer PPAR-related safety concerns.