Oxidized LDL and the metabolic syndrome. (December 2008)

• Record Type: Journal Article
• Authors: Holvoet, Paul; De Keyzer, Dieuwke; Jacobs Jr, David R
• Is Part Of: Future lipidology. Volume 3:Number 6(2008)
• Page Start: 637
• Page End: 649
• Publication Date: 2008-12
• Subjects: atherosclerosis -- inflammation -- metabolic syndrome -- obesity -- oxidative stress -- oxidized LDL; Lipids -- Periodicals; 616.3997
• DOI: 10.2217/17460875.3.6.637
• Languages: English
• ISSNs: 1746-0875

Abstract

The metabolic syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension and insulin resistance. It is associated with a high cardiovascular risk that can only partially be explained by its components. There is evidence that low-grade inflammation and high oxidative stress add to this risk. Oxidized LDL, a marker of lipoprotein-associated oxidative stress, is an emerging cardiovascular risk factor. In this review, we demonstrate that the metabolic syndrome exacerbates oxidized LDL in a feedback loop. We introduce molecular mechanisms underlying this loop. Finally, we demonstrate that weight loss and statin treatment lower metabolic syndrome factors associated with a reduction of oxidized LDL. The current data warrant further investigation into the role of lifestyle and therapeutic interventions that inhibit tissue-associated oxidation of LDL in the prevention of the metabolic syndrome.