A nomogram for predicting recurrence after complete resection for thymic epithelial tumors based on the TNM classification: A multi‐institutional retrospective analysis. Issue 8 (28th March 2019)

• Record Type: Journal Article
• Authors: Yun, Jae Kwang; Lee, Geun Dong; Kim, Hyeong Ryul; Kim, Dong Kwan; Zo, Jae Il; Shim, Young Mog; Kang, Chang Hyun; Kim, Young Tae; Paik, Hyo Chae; Chung, Kyoung Young
• Is Part Of: Journal of surgical oncology. Volume 119:Issue 8(2019)
• Page Start: 1161
• Page End: 1169
• Publication Date: 2019-03-28
• Subjects: calibration -- nomogram -- recurrence -- staging -- thymic malignancy; Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.25462
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract: Objectives: This study aimed to compare the predictive ability between the Masaoka‐Koga (M‐K) staging system and the 8th TNM staging system for the recurrence of thymic epithelial tumors (TETs). In addition, a nomogram was developed on the basis of the proposed TNM classification to predict individual recurrence rate. Methods: A retrospective study was performed on 445 patients who underwent complete resection (R0) of TETs between January 2000 and February 2013. Concordance index (C‐index) was used as a statistical indicator to quantify the prediction power of the prediction models. Results: In multivariate analysis, tumor stage and WHO classification were independent recurrence factors in a predictive model on the basis of M‐K and TNM stage. The TNM model showed higher C‐index than the M‐K model (0.837 vs 0.817). The nomogram, on the basis of the TNM model, revealed a highly predictive performance, with a bootstrap‐corrected C‐index of 0.85 (95% CI, 0.76 to 0.93). Conclusions: A predictive model based on the 8th TNM stage was slightly better than that based on M‐K stage with respect to recurrence after R0 of TETs. The proposed nomogram could be applied to estimate the individual recurrence rate and make decisions for proper surveillance.