Mild encephalopathy with reversible splenium lesion (MERS) in a patient with COVID-19. (September 2020)

• Record Type: Journal Article
• Authors: Kakadia, Bhavika; Ahmed, Jaffer; Siegal, Todd; Jovin, Tudor G.; Thon, Jesse M.
• Is Part Of: Journal of clinical neuroscience. Volume 79(2020)
• Page Start: 272
• Page End: 274
• Publication Date: 2020-09
• Subjects: MERS -- Mild encephalopathy with reversible splenium lesion -- COVID-19 -- SARS-CoV-2; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.07.009
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: MERS is characterized by fever, encephalopathy, and a reversible splenium lesion. MERS has been associated with infection, potentially as an autoimmune response. MERS has not previously been described in conjunction with COVID-19. We present the first reported case of MERS in the setting of SARS-CoV-2 antibodies. Abstract: Neurological complications of coronavirus 2019 (COVID-19) are common, and novel manifestations are increasingly being recognized. Mild encephalopathy with reversible splenium lesion (MERS) is a syndrome that has been associated with viral infections, but not previously with COVID-19. In this report, we describe the case of a 69 year-old man who presented with fever and encephalopathy in the setting of a diffusion-restricting splenium lesion, initially mimicking an ischemic stroke. A comprehensive infectious workup revealed positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies, and a pro-inflammatory laboratory profile characteristic of COVID-19 infection. His symptoms resolved and the brain MRI findings completely normalized on repeat imaging, consistent with MERS. This case suggests that MERS may manifest as an autoimmune response to SARS-CoV-2 infection and should be considered in a patient with evidence of recent COVID-19 infection and the characteristic MERS clinico-radiological syndrome.