The impact of the gut microbiota on prognosis after surgery for colorectal cancer – a systematic review and meta‐analysis. Issue 2 (30th April 2020)

• Record Type: Journal Article
• Authors: Colov, Emilie Palmgren; Degett, Thea Helene; Raskov, Hans; Gögenur, Ismail
• Other Names: Andersen Åse Bengård guestEditor.; Nejsum Lene N. guestEditor.
• Is Part Of: Apmis. Volume 128:Issue 2(2020)
• Page Start: 162
• Page End: 176
• Publication Date: 2020-04-30
• Subjects: Colorectal cancer -- prognosis -- gut microbiota -- cancer surgery -- gastrointestinal pathology -- prognostic markers; Pathology -- Periodicals; Microbiology -- Periodicals; Immunology -- Periodicals; 572
• DOI: 10.1111/apm.13032
• Languages: English
• ISSNs: 0903-4641

Abstract

Abstract : The aim of this study was to conduct a systematic review of the association between gut microbiota and prognosis after colorectal cancer surgery. The review was conducted according to the PRISMA guidelines. A systematic literature search was conducted in PubMed, Embase, and Scopus. Studies examining the association between gut microbiota and survival after colorectal cancer surgery were identified. Secondary outcomes were association with cancer stage and immune infiltration of tumor. A total of 27 studies were included in the review. Fusobacterium nucleatum was the most frequently examined bacterium, and the meta‐analysis showed that high level of F. nucleatum was significantly associated with decreased overall survival, hazard ratio of 1.63 (95% confidence interval 1.23–2.16) for unadjusted data, and hazard ratio of 1.47 (95% confidence interval 1.08–1.98) for adjusted data. Association between higher tumor stage and F. nucleatum was reported in ten studies, and two studies found an association with unfavorable tumor infiltration of immune cells. Three out of five studies examining Bacteroides fragilis found an association with decreased survival, advanced tumor stage, or unfavorable immune infiltration of tumor. High levels of F. nucleatum and possibly B. fragilis were associated with worse prognosis after surgery for colorectal cancer.