Progress update from the hippocampal subfields group. Issue 1 (13th June 2019)

• Record Type: Journal Article
• Authors: Olsen, Rosanna K.; Carr, Valerie A.; Daugherty, Ana M.; La Joie, Renaud; Amaral, Robert S.C.; Amunts, Katrin; Augustinack, Jean C.; Bakker, Arnold; Bender, Andrew R.; Berron, David; Boccardi, Marina; Bocchetta, Martina; Burggren, Alison C.; Chakravarty, M. Mallar; Chételat, Gaël; de Flores, Robin; DeKraker, Jordan; Ding, Song‐Lin; Geerlings, Mirjam I.; Huang, Yushan; Insausti, Ricardo; Johnson, Elliott G.; Kanel, Prabesh; Kedo, Olga; Kennedy, Kristen M.; Keresztes, Attila; Lee, Joshua K.; Lindenberger, Ulman; Mueller, Susanne G.; Mulligan, Elizabeth M.; Ofen, Noa; Palombo, Daniela J.; Pasquini, Lorenzo; Pluta, John; Raz, Naftali; Rodrigue, Karen M.; Schlichting, Margaret L.; Lee Shing, Yee; Stark, Craig E.L.; Steve, Trevor A.; Suthana, Nanthia A.; Wang, Lei; Werkle‐Bergner, Markus; Yushkevich, Paul A.; Yu, Qijing; Wisse, Laura E.M.;
• Is Part Of: Alzheimer's & dementia. Volume 11:Issue 1(2019)
• Page Start: 439
• Page End: 449
• Publication Date: 2019-06-13
• Subjects: Hippocampus -- Volumetry -- Human -- Neuroimaging -- Structural imaging -- Neuroanatomy -- Histology -- Cytoarchitecture -- ex vivo; Alzheimer's disease -- Periodicals; Alzheimer's disease -- Diagnosis -- Periodicals; Dementia -- Periodicals; Dementia -- Diagnosis -- Periodicals; 616.831
• DOI: 10.1016/j.dadm.2019.04.001
• Languages: English
• ISSNs: 2352-8729

Abstract

Abstract: Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide. Highlights: Harmonization of MRI‐based segmentation of medial temporal regions is needed. The Hippocampal Subfield Group includes >200 imaging and anatomy experts worldwide. Reliable and valid protocol based on specialized histology data set in development. A modified Delphi procedure is used to determine consensus on protocol rules. Final protocol will provide subfield delineation in hippocampal body, head, and tail.