Cerium Oxide Nanoparticles: Cerium Oxide Nanoparticles: Advances in Biodistribution, Toxicity, and Preclinical Exploration (Small 20/2020). Issue 20 (22nd May 2020)

• Record Type: Journal Article
• Authors: Casals, Eudald; Zeng, Muling; Parra‐Robert, Marina; Fernández‐Varo, Guillermo; Morales‐Ruiz, Manuel; Jiménez, Wladimiro; Puntes, Víctor; Casals, Gregori
• Is Part Of: Small. Volume 16:Issue 20(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-05-22
• Subjects: antioxidant nanoparticles -- cerium oxide nanoparticles -- liver diseases -- pharmacokinetics of nanoparticles -- preclinical exploration; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202070111
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : The benefits of classic antioxidants can be translated to clinical therapies owing to the superior activity of CeO2 nanoparticles as redox buffers. In article number 1907322, Wladimiro Jiménez, Víctor Puntes, Gregori Casals, and co‐workers present a historical background of their development for medicine, and analyze their pharmacokinetics, toxicity, and therapeutic value, focusing on the liver where they accumulate. Finally, considerations for medical nanoparticles to reach the clinic are discussed in detail.