Wireless Manipulation of Magnetic/Piezoelectric Micromotors for Precise Neural Stem‐Like Cell Stimulation. (22nd January 2020)

• Record Type: Journal Article
• Authors: Liu, Lu; Chen, Bin; Liu, Kun; Gao, Junbin; Ye, Yicheng; Wang, Zhen; Qin, Ni; Wilson, Daniela A.; Tu, Yingfeng; Peng, Fei
• Is Part Of: Advanced functional materials. Volume 30:Number 11(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-22
• Subjects: magnetic control -- micromotor -- neuronal regeneration -- precise stimulation -- wireless ultrasound; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201910108
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Precise neural electrical stimulation, which is a means of promoting neuronal regeneration, is a promising solution for patients with neurotrauma and neurodegenerative diseases. In this study, wirelessly controllable targeted motion and precise stimulation at the single‐cell level using S.platensis @Fe3 O4 @tBaTiO3 micromotors are successfully demonstrated for the first time. A highly versatile and multifunctional biohybrid soft micromotor is fabricated via the integration of S.platensis with magnetic Fe3 O4 nanoparticles and piezoelectric BaTiO3 nanoparticles. The results show that this micromotor system can achieve navigation in a highly controllable manner under a low‐strength rotating magnetic field. The as‐developed system can achieve single‐cell targeted motion and then precisely induce the differentiation of the targeted neural stem‐like cell by converting ultrasonic energy to an electrical signal in situ owing to the piezoelectric effect. This new approach toward the high‐precision stimulation of neural stem‐like cells opens up new applications for micromotors and has excellent potential for precise neuronal regenerative therapies. Abstract : A new strategy for precise neural stem‐like cell stimulation is demonstrated. The S.platensis @Fe3 O4 @tBaTiO3 micromotor could reach the targeted neural stem‐like cell under the guidance of a rotating magnetic field. With the presence of an ultrasound field and integrated piezoelectric tBaTiO3 in the micromotor, electrical signals are generated in situ, leading to the differentiation of the targeted cell.