Genome‐wide association for milk production and lactation curve parameters in Holstein dairy cows. (1st October 2019)

• Record Type: Journal Article
• Authors: Atashi, Hadi; Salavati, Mazdak; De Koster, Jenne; Ehrlich, Jim; Crowe, Mark; Opsomer, Geert; Hostens, Miel
• Other Names: McLoughlin Niamh investigator.; Fahey Alan investigator.; Matthews Elizabeth investigator.; Santoro Andreia investigator.; Byrne Colin investigator.; Rudd Pauline investigator.; O'Flaherty Roisin investigator.; Hallinan Sinead investigator.; Wathes Claire investigator.; Cheng Zhangrui investigator.; Fouladi Ali investigator.; Pollott Geoff investigator.; Werling Dirk investigator.; Sanz Bernardo Beatriz investigator.; Wylie Alistair investigator.; Bell Matt investigator.; Vaneetvelde Mieke investigator.; Hermans Kristof investigator.; Opsomer Geert investigator.; Moerman Sander investigator.; Koster Jenne investigator.; Bogaert Hannes investigator.; Vandepitte Jan investigator.; Vandevelde Leila investigator.; Vanranst Bonny investigator.; Hoglund Johanna investigator.; Dahl Susanne investigator.; Ostergaard Soren investigator.; Rothmann Janne investigator.; Krogh Mogens investigator.; Meyer Else investigator.; Gaillard Charlotte investigator.; Ettema Jehan investigator.; Rousing Tine investigator.; Signorelli Federica investigator.; Napolitano Francesco investigator.; Moioli Bianca investigator.; Crisà Alessandra investigator.; Buttazzoni Luca investigator.; McClure Jennifer investigator.; Matthews Daragh investigator.; Kearney Francis investigator.; Cromie Andrew investigator.; McClure Matt investigator.; Zhang Shujun investigator.; Chen Xing investigator.; Chen Huanchun investigator.; Zhao Junlong investigator.; Yang Liguo investigator.; Hua Guohua investigator.; Tan Chen investigator.; Wang Guiqiang investigator.; Bonneau Michel investigator.; Pompozzi Andrea investigator.; Pearn Armin investigator.; Evertson Arnold investigator.; Kosten Linda investigator.; Fogh Anders investigator.; Andersen Thomas investigator.; Lucey Matthew investigator.; Elsik Chris investigator.; Conant Gavin investigator.; Taylor Jerry investigator.; Gengler Nicolas investigator.; Georges Michel investigator.; Colinet Frédéric investigator.; Ramos Pamplona Marilou investigator.; Hammami Hedi investigator.; Bastin Catherine investigator.; Takeda Haruko investigator.; Laine Aurelie investigator.; Van Laere Anne‐Sophie investigator.; Schulze Martin investigator.; Palma Vera Sergio investigator.; Ferris Conrad investigator.; Marchitelli Cinzia investigator.;
• Is Part Of: Journal of animal breeding and genetics. Volume 137:Number 3(2020)
• Page Start: 292
• Page End: 304
• Publication Date: 2019-10-01
• Subjects: genome‐wide association study -- Holstein -- lactation curve -- milk yield; Livestock -- Breeding -- Periodicals; Livestock -- Genetics -- Periodicals; 636.0820
• DOI: 10.1111/jbg.12442
• Languages: English
• ISSNs: 0931-2668

Abstract

Abstract: The aim of this study was to identify genomic regions associated with 305‐day milk yield and lactation curve parameters on primiparous ( n = 9, 910) and multiparous ( n = 11, 158) Holstein cows. The SNP solutions were estimated using a weighted single‐step genomic BLUP approach and imputed high‐density panel (777k) genotypes. The proportion of genetic variance explained by windows of 50 consecutive SNP (with an average of 165 Kb) was calculated, and regions that accounted for more than 0.50% of the variance were used to search for candidate genes. Estimated heritabilities were 0.37, 0.34, 0.17, 0.12, 0.30 and 0.19, respectively, for 305‐day milk yield, peak yield, peak time, ramp, scale and decay for primiparous cows. Genetic correlations of 305‐day milk yield with peak yield, peak time, ramp, scale and decay in primiparous cows were 0.99, 0.63, 0.20, 0.97 and −0.52, respectively. The results identified three windows on BTA14 associated with 305‐day milk yield and the parameters of lactation curve in primi‐ and multiparous cows. Previously proposed candidate genes for milk yield supported by this work include GRINA, CYHR1, FOXH1, TONSL, PPP1R16A, ARHGAP39, MAF1, OPLAH and MROH1, whereas newly identified candidate genes are MIR2308, ZNF7, ZNF34, SLURP1, MAFA and KIFC2 (BTA14). The protein lipidation biological process term, which plays a key role in controlling protein localization and function, was identified as the most important term enriched by the identified genes.