Association between plasma retinol levels and the risk of all‐cause mortality in general hypertensive patients: A nested case‐control study. Issue 5 (30th April 2020)

• Record Type: Journal Article
• Authors: Li, Huan; He, Panpan; Lin, Tengfei; Guo, Huiyuan; Li, Youbao; Song, Yun; Wang, Binyan; Liu, Chengzhang; Liu, Lishun; Li, Jianping; Zhang, Yan; Huo, Yong; Zhou, Houqing; Yang, Yan; Ling, Wenhua; Wang, Xiaobin; Zhang, Hao; Xu, Xiping; Qin, Xianhui
• Is Part Of: Journal of clinical hypertension. Volume 22:Issue 5(2020)
• Page Start: 906
• Page End: 913
• Publication Date: 2020-04-30
• Subjects: all‐cause mortality -- hypertension -- retinol -- systolic blood pressure -- vitamin E; Hypertension -- Periodicals; 616.132
• DOI: 10.1111/jch.13866
• Languages: English
• ISSNs: 1524-6175

Abstract

Abstract: To evaluate the association between plasma retinol levels with all‐cause mortality and investigate the possible effect modifiers in general hypertensive patients with no previous cardiovascular disease (CVD). This case‐control study was nested in the China Stroke Primary Prevention Trial (CSPPT), a randomized, double‐blind, controlled trial conducted in 32 communities in Anhui and Jiangsu provinces in China. The current study included 617 cases of all‐cause mortality and 617 controls matched on age (≤1 year), sex, treatment group, and study site. All‐cause mortality was the main outcome in this analysis, which included death due to any reason. The median follow‐up duration was 4.5 years. Overall, there was a U‐shaped relation of plasma retinol with all‐cause mortality. In the threshold effect analysis, the risk of all‐cause mortality significantly decreased with the increase in plasma retinol (per 10 μg/dL increments: OR, 0.73; 95% CI: 0.61‐0.87) in participants with plasma retinol <58.3 μg/dL and increased with the increase in plasma retinol (per 10 μg/dL increments: OR, 1.08; 95% CI: 1.01‐1.16) in those with plasma retinol ≥58.3 μg/L. In participants with plasma retinol <58.3 μg/dL, a stronger inverse association was observed in those with higher time‐averaged SBP (≥140 vs <140 mm Hg; P ‐interaction = .034), or higher vitamin E levels (≥11.5 [quartile 4]; vs <11.5 μg/mL; P ‐interaction = .013). The present study demonstrated that there was a U‐shaped relationship of plasma retinol levels with the risk of all‐cause mortality in general hypertensive patients, with a turning point around 58.3 μg/dL.