Galactomannan antigen and Aspergillus antibody responses in a transplant recipient with multiple invasive fungal infections. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Dupont, D.; Geffriaud, T.; Boibieux, A.; Rimmele, T.; Picot, S.; Persat, F.
• Is Part Of: JMM case reports. Volume 2:Issue 2(2015)
• Publication Date: 2015-04
• Subjects: antibody -- Aspergillus -- ELISA -- galactomannans -- Western blotting; Medical microbiology -- Periodicals; 616.9041
• DOI: 10.1099/jmmcr.0.000026
• Languages: English
• ISSNs: 2053-3721

Abstract

Abstract : Introduction: We report Aspergillus antigen and antibody responses in a case of multiple invasive fungal diseases. Case presentation: The patient, a double‐lung transplant recipient, had candidaemia and invasive pulmonary aspergillosis with cerebral involvement. The follow‐up of the serum Aspergillus galactomannan antigen by ELISA showed a level increase that correlated with the patient's aggravation. It was retrospectively completed by kinetics analysis using different anti‐ Aspergillus antibody assays (ELISA and Western blotting). Conclusion: A balance between the Aspergillus antigen and anti‐ Aspergillus antibodies was shown using different anti‐ Aspergillus antibody assays. The results of these two antibody techniques appeared rather congruent.