Neuromyelitis optica spectrum disorders in children and adolescents. (30th August 2016)

• Record Type: Journal Article
• Authors: Tenembaum, Silvia; Chitnis, Tanuja; Nakashima, Ichiro; Collongues, Nicolas; McKeon, Andrew; Levy, Michael; Rostasy, Kevin
• Is Part Of: Neurology. Volume 87:Number 9(2016)Supplement 2
• Publication Date: 2016-08-30
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000002824
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Neuromyelitis optica (NMO) is a severe autoimmune disease of the CNS characterized by recurrent inflammatory events primarily involving the optic nerves and spinal cord. NMO is infrequent in children, but early recognition is important to start adequate treatment. In this article, we review the evolving diagnostic criteria of NMO and provide an update on the clinical and neuroimaging spectrum of the disorder in pediatric patients, including current knowledge on immunopathogenesis and treatment recommendations for children with NMO.