Voltammetric responses at modified electrodes and aggregation effects of two anticancer molecules: irinotecan and sunitinib. (19th October 2020)

• Record Type: Journal Article
• Authors: Vercelli, Barbara; Crotti, Sara; Agostini, Marco
• Is Part Of: New journal of chemistry. Volume 44:Number 42(2020)
• Page Start: 18233
• Page End: 18241
• Publication Date: 2020-10-19
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d0nj03896b
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Voltammetric analyses of two anticancer molecules at modified electrodes and influence of aggregate formation on their differential pulse voltammetry (DPV) responses. Abstract : The voltammetric responses of two anticancer molecules irinotecan (ITC) and sunitinib (SUN) were investigated at glassy carbon (GC) and indium tin oxide (ITO) electrodes bare or modified with carbon nanotubes (NTs), NT–Nafion composites (NafionNTs) and poly(3, 4-ethylenedioxy-thiophene) (PEDOT). Bare GC electrodes revealed to be the most suitable for the detection of drugs at low concentration levels. Differential pulse voltammetry (DPV) analyses showed that the responses of the anticancer molecules are affected by the formation of aggregates. In particular, aggregation of SUN results in the formation of H-aggregates. DPV analysis extended to human plasma samples revealed the drugs in micromolar concentrations with good reproducibility.