Front Cover: Proteome Profile of Endogenous Retrotransposon‐Associated Complexes in Human Embryonic Stem Cells. Issue 15 (1st August 2019)

• Record Type: Journal Article
• Authors: Vuong, Linh M.; Pan, Songqin; Donovan, Peter J.
• Is Part Of: Proteomics. Volume 19:Issue 15(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-08-01
• Subjects: Proteins -- Separation -- Periodicals; Bioinformatics -- Periodicals; Proteomics -- Periodicals; Genomes -- Periodicals; Molecular genetics -- Periodicals; 572.605
• DOI: 10.1002/pmic.201970131
• Languages: English
• ISSNs: 1615-9853

Abstract

Abstract : DOI: 10.1002/pmic.201900169 Long Interspersed Element‐1 (L1) is a major transposable element present in the human genome. L1 activity is implicated in various human diseases and cancer. Depicted here is a colony of human embryonic stem cell (ESCs) expressing the endogenous L1‐encoded ORF1 protein. ORF1p appears as distinct cytoplasmic foci (green) close to nuclei expressing the stem cell marker, OCT4 (red). Phalloidin‐Cyan (blue) stains actin. In article number 1900169, Vuong et al. identify cellular proteins associated with ORF1p in human ESCs. Understanding ORF1p function is likely critical to deciphering how the L1 element has evolved with our species and impacts our biology and physiology.