Direct Synthesis of Carbamoyl Fluorides by CO2 Deoxyfluorination. (5th August 2019)

• Record Type: Journal Article
• Authors: Onida, Killian; Tlili, Anis
• Is Part Of: Angewandte Chemie. Volume 131:Number 36(2019)
• Page Start: 12675
• Page End: 12678
• Publication Date: 2019-08-05
• Subjects: Amine -- Carbamoylfluoride -- Deoxyfluorierung -- Fluor -- Kohlendioxid; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201907354
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Herein, a new concept for the direct synthesis of carbamoyl fluoride derivatives is disclosed. The developed method makes use of CO2 as an inexpensive and abundant C1 source; a variety of amines were successfully converted in the presence of a deoxyfluorinating reagent. The corresponding products were often obtained in excellent yields under mild reaction conditions (1 atm and room temperature). The reaction was easily scaled up, demonstrating the efficiency of the developed process. Abstract : CO2 ‐Deoxyfluorierung : Die reduktive Fluorierung von CO2 ermöglicht die Synthese von Carbamoylfluoriden. Die Reaktionen können leicht in größerem Maßstab durchgeführt werden, und das Konzept wurde für die Synthese von 13 C‐markierten Carbamoylverbindungen genutzt.