Cytological features of breast implant‐associated anaplastic large cell lymphoma in pleural effusion. Issue 11 (26th July 2019)

• Record Type: Journal Article
• Authors: D'Alessandris, Nicoletta; Lucatelli, Pierleone; Tripodi, Domenico; Amabile, Maria Ida; Ascoli, Valeria
• Is Part Of: Diagnostic cytopathology. Volume 47:Issue 11(2019)
• Page Start: 1213
• Page End: 1217
• Publication Date: 2019-07-26
• Subjects: ALK‐negative anaplastic large cell lymphoma -- breast implant -- cytological diagnosis -- pleural effusion; Cytodiagnosis -- Periodicals; Pathology, Cellular -- Periodicals; Cytology -- Periodicals; 616.07582
• DOI: 10.1002/dc.24287
• Languages: English
• ISSNs: 8755-1039

Abstract

Abstract: Breast implant‐associated anaplastic large cell lymphoma (BIA‐ALCL) is a very rare CD30‐positive ALK‐negative T‐cell non‐Hodgkin lymphoma included as a provisional entity in the 2017 WHO classification of lymphoid neoplasms. BIA‐ALCL arises as proliferating cells over the surface of the implant. It is generally an indolent disease if confined within the fibrous capsule. In contrast, mass and/or infiltration beyond the capsule is much more aggressive. This report describes a case of infiltrative BIA‐ALCL with massive pleural effusion containing hallmark BIA‐ALCL cells showing the characteristic morphologic appearance of high‐grade anaplastic lymphoma, CD30‐positive but ALK‐negative with variable staining for T‐cell antigens. Detailed cytological features of BIA‐ALCL in pleural fluid are described along with the results of a literature search performed for BIA‐ALCL cases with pleural effusion. This report expands the spectrum of BIA‐ALCL pathology to include chest wall involvement and pleural effusion.