Direct Synthesis of Carbamoyl Fluorides by CO2 Deoxyfluorination. Issue 36 (5th August 2019)

• Record Type: Journal Article
• Authors: Onida, Killian; Tlili, Anis
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 36(2019)
• Page Start: 12545
• Page End: 12548
• Publication Date: 2019-08-05
• Subjects: amines -- carbamoyl fluorides -- carbon dioxide -- deoxyfluorination -- fluorine; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201907354
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Herein, a new concept for the direct synthesis of carbamoyl fluoride derivatives is disclosed. The developed method makes use of CO2 as an inexpensive and abundant C1 source; a variety of amines were successfully converted in the presence of a deoxyfluorinating reagent. The corresponding products were often obtained in excellent yields under mild reaction conditions (1 atm and room temperature). The reaction was easily scaled up, demonstrating the efficiency of the developed process. Abstract : CO2 deoxyfluorination : The reductive fluorination of CO2 enables the synthesis of carbamoyl fluorides. The reactions are easily scalable, and the concept was exploited for the synthesis of 13 C‐labeled carbamoyl compounds.