A Nanozyme with Photo‐Enhanced Dual Enzyme‐Like Activities for Deep Pancreatic Cancer Therapy. (30th July 2019)

• Record Type: Journal Article
• Authors: Li, Shanshan; Shang, Lu; Xu, Bolong; Wang, Shunhao; Gu, Kai; Wu, Qingyuan; Sun, Yun; Zhang, Qinghua; Yang, Hailong; Zhang, Fengrong; Gu, Lin; Zhang, Tierui; Liu, Huiyu
• Is Part Of: Angewandte Chemie. Volume 131:Number 36(2019)
• Page Start: 12754
• Page End: 12761
• Publication Date: 2019-07-30
• Subjects: Enzym-artige Aktivität -- Katalyse -- Nanozyme -- Photothermische Therapie -- Tumortherapie; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201904751
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Nanozymes have attracted extensive interest owing to their high stability, low cost and easy preparation, especially in the field of cancer therapy. However, the relatively low catalytic activity of nanozymes in the tumor microenvironment (TME) has limited their applications. Herein, we report a novel nanozyme (PtFe@Fe3 O4 ) with dual enzyme‐like activities for highly efficient tumor catalytic therapy. PtFe@Fe3 O4 shows the intrinsic photothermal effect as well as photo‐enhanced peroxidase‐like and catalase‐like activities in the acidic TME, thereby effectively killing tumor cells and overcoming the tumor hypoxia. Importantly, a possible photo‐enhanced synergistic catalytic mechanism of PtFe@Fe3 O4 was first disclosed. We believe that this work will advance the development of nanozymes in tumor catalytic therapy. Abstract : Doppelter Angriff : Ein neuartiges Nanozym (PtFe@Fe3 O4 ) mit dualer Enzym‐artiger Aktivität wurde für die katalytische Therapie von Bauchspeicheldrüsenkrebs entwickelt. Das Nanozym zeigt photoverstärkte Peroxidase (POD)‐ und Katalase (CAT)‐artige Aktivitäten in der sauren Tumormikroumgebung sowie einen intrinsischen photothermischen Effekt. Es tötet Tumorzellen effektiv ab und überwindet die Tumorhypoxie.