MScanFit motor unit number estimation and muscle velocity recovery cycle recordings in diabetic polyneuropathy. Issue 11 (November 2020)
- Record Type:
- Journal Article
- Title:
- MScanFit motor unit number estimation and muscle velocity recovery cycle recordings in diabetic polyneuropathy. Issue 11 (November 2020)
- Main Title:
- MScanFit motor unit number estimation and muscle velocity recovery cycle recordings in diabetic polyneuropathy
- Authors:
- Kristensen, A.G.
Khan, K.S.
Bostock, H.
Khan, B.S.
Gylfadottir, S.
Andersen, H.
Finnerup, N.B.
Jensen, T.S.
Tankisi, H. - Abstract:
- Highlights: MScanFit is more sensitive in showing motor unit loss than nerve conduction studies in diabetic neuropathy. MScanFit reveals motor involvement equal to sensory in diabetic neuropathy. Muscle velocity recovery cycles (MVRCs) do not provide additional information in diabetic neuropathy. Abstract: Objective: Motor Unit Number Estimation (MUNE) methods may be valuable in tracking motor unit loss in diabetic polyneuropathy (DPN). Muscle Velocity Recovery Cycles (MVRCs) provide information about muscle membrane properties. This study aimed to examine the utility of the MScanFit MUNE in detecting motor unit loss and to test whether the MVRCs could improve understanding of DPN pathophysiology. Methods: Seventy-nine type-2 diabetic patients were compared to 32 control subjects. All participants were examined with MScanFit MUNE and MVRCs in anterior tibial muscle. Lower limb nerve conduction studies (NCS) in peroneal, tibial and sural nerves were applied to diagnose large fiber neuropathy. Results: NCS confirmed DPN for 47 patients (DPN + ), with 32 not showing DPN (DPN−). MScanFit showed significantly decreased MUNE values and increased motor unit sizes, when comparing DPN + patients with controls (MUNE = 71.3 ± 4.7 vs 122.7 ± 3.8), and also when comparing DPN− patients (MUNE = 103.2 ± 5.1) with controls. MVRCs did not differ between groups. Conclusions: MScanFit is more sensitive in showing motor unit loss than NCS in type-2 diabetic patients, whereas MVRCs do notHighlights: MScanFit is more sensitive in showing motor unit loss than nerve conduction studies in diabetic neuropathy. MScanFit reveals motor involvement equal to sensory in diabetic neuropathy. Muscle velocity recovery cycles (MVRCs) do not provide additional information in diabetic neuropathy. Abstract: Objective: Motor Unit Number Estimation (MUNE) methods may be valuable in tracking motor unit loss in diabetic polyneuropathy (DPN). Muscle Velocity Recovery Cycles (MVRCs) provide information about muscle membrane properties. This study aimed to examine the utility of the MScanFit MUNE in detecting motor unit loss and to test whether the MVRCs could improve understanding of DPN pathophysiology. Methods: Seventy-nine type-2 diabetic patients were compared to 32 control subjects. All participants were examined with MScanFit MUNE and MVRCs in anterior tibial muscle. Lower limb nerve conduction studies (NCS) in peroneal, tibial and sural nerves were applied to diagnose large fiber neuropathy. Results: NCS confirmed DPN for 47 patients (DPN + ), with 32 not showing DPN (DPN−). MScanFit showed significantly decreased MUNE values and increased motor unit sizes, when comparing DPN + patients with controls (MUNE = 71.3 ± 4.7 vs 122.7 ± 3.8), and also when comparing DPN− patients (MUNE = 103.2 ± 5.1) with controls. MVRCs did not differ between groups. Conclusions: MScanFit is more sensitive in showing motor unit loss than NCS in type-2 diabetic patients, whereas MVRCs do not provide additional information. Significance: The MScanFit results suggest that motor changes are seen as early as sensory, and the role of axonal membrane properties in DPN pathophysiology should be revisited. … (more)
- Is Part Of:
- Clinical neurophysiology. Volume 131:Issue 11(2020:Nov.)
- Journal:
- Clinical neurophysiology
- Issue:
- Volume 131:Issue 11(2020:Nov.)
- Issue Display:
- Volume 131, Issue 11 (2020)
- Year:
- 2020
- Volume:
- 131
- Issue:
- 11
- Issue Sort Value:
- 2020-0131-0011-0000
- Page Start:
- 2591
- Page End:
- 2599
- Publication Date:
- 2020-11
- Subjects:
- Diabetic polyneuropathy -- MScanFit -- Motor unit number estimation -- Muscle velocity recovery cycles -- Motor unit loss
Neurophysiology -- Periodicals
Electroencephalography -- Periodicals
Electromyography -- Periodicals
Neurology -- Periodicals
612.8 - Journal URLs:
- http://www.sciencedirect.com/science/journal/13882457 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.clinph.2020.07.017 ↗
- Languages:
- English
- ISSNs:
- 1388-2457
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3286.310645
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 14772.xml