Clinical, MRI and 18F-FDG-PET/CT analysis of progressive supranuclear palsy. (October 2020)

• Record Type: Journal Article
• Authors: Zhao, Ping; Zhang, Benshu; Gao, Shuo; Li, Xin
• Is Part Of: Journal of clinical neuroscience. Volume 80(2020)
• Page Start: 318
• Page End: 323
• Publication Date: 2020-10
• Subjects: PSP Progressive supranuclear palsy -- PPS Parkinson-plus syndromes -- MRI magnetic resonance imaging -- FDG PET fluorodeoxyglucose positron emission tomography -- CT computed tomography -- PD Parkinson's disease -- AD Alzheimer disease -- UPDRS Unified Parkinson's disease rating scale -- H–Y Hoehn–Yahr -- MMSE mini-mental state examination -- ADL ctivities of daily living -- NFP neurofilament protein -- CBD corticobasal degeneration -- RS Richardson's syndrome -- PSP-P PSP-parkinsonism -- PSP-CBS PSP-corticobasal syndrome -- L-dopa levodopa -- PSP-F PSP with Frontal Presentation -- PSP-C PSP with predominant cerebellar ataxia -- DLB dementia with Lewy bodies -- MSA multiple system atrophy -- IPD idiopathic Parkinson's disease; Neurodegenerative disease -- Atypical Parkinsonian syndrome -- Clinical Diagnosis -- Positron emission tomography -- Retrospective analysis; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.06.008
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: The clinical and magnetic resonance imaging features of PSP were analyzed. FDG positron emission tomography brain imaging was performed. Characteristics of cerebral glucose metabolism were explored to increase accuracy. Studying the clinical and MRI features of PSP can be helpful in the diagnosis. Abstract: Background: Progressive supranuclear palsy (PSP) is a kind of neurodegenerative disease. In the present study, the clinical and magnetic resonance imaging (MRI) features of PSP were analyzed, and fluorodeoxyglucose positron emission tomography (FDG PET) brain imaging was performed to preliminarily explore the characteristics of cerebral glucose metabolism, so as to make a more accurate and differential diagnosis. Methods: In accordance with the diagnostic criteria, the clinical symptoms, the unified Parkinson's disease rating scale (UPDRS), the mini-mental state examination (MMSE), the activities of daily living (ADL), and the magnetic resonance image (MRI) of 19 patients with PSP were examined and FDG-PET brain imaging was performed. Visual analysis and statistical parameter diagram were used to analyze the characteristics. Results: Concerning the clinical characteristics, 84.21% of the patients with PSP had early recurrent falls, 63.15% had vertical supranuclear ophthalmoplegia, and 47.37% had symptoms of dementia. The MRI scans showed that 57.89% of the patients had a "hummingbird" sign in the middle sagittal position. The FDG-PET imaging indicated that glucose metabolism in the midbrain and frontal lobe was decreased in patients with PSP. Conclusions: Studying the clinical and MRI features of patients with PSP can be helpful in the diagnosis, especially as some signs could be found in the early stage by FDG PET, enhancing early diagnosis and differentiation.