The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men. (November 2020)

• Record Type: Journal Article
• Authors: Hirata, Aya; Kakino, Akemi; Okamura, Tomonori; Usami, Yoko; Fujita, Yoshiko; Kadota, Aya; Fujiyoshi, Akira; Hisamatsu, Takashi; Kondo, Keiko; Segawa, Hiroyoshi; Sawamura, Tatsuya; Miura, Katsuyuki; Ueshima, Hirotsugu
• Is Part Of: Atherosclerosis. Volume 313(2020)
• Page Start: 20
• Page End: 25
• Publication Date: 2020-11
• Subjects: Modified high-density lipoprotein -- LOX-1 ligand containing ApoAI -- Lectin-like oxidized low-density lipoprotein receptor-1 -- Coronary artery calcification -- Japan; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2020.09.013
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: Dysfunctional high-density lipoprotein (HDL) is a risk factor for cardiovascular disease (CVD) beyond HDL concentrations. Recently, a novel method has been introduced to measure LOX-1 ligand containing apolipoprotein AI (LAA), which is an indicator of various types of modified HDL with binding capacity to LOX-1 and related to impaired anti-atherogenic functions of HDL. This study aimed to examine the relationship between LAA as a novel marker of dysfunctional HDL and coronary artery calcification (CAC). Methods: We selected 910 community-dwelling Japanese men aged 40–79 years without a history of CVD. The odds ratios per 1SD of LAA for the presence of CAC (Agatston score >10) were estimated using logistic regression model adjusted for confounders, including HDL-C or HDL particle (HDL-P) concentration. In addition, we performed further analysis stratified by age (<65 and ≥ 65 years). Results: The mean age of the participants was 63.6 years, and the median LAA was 187.0 ng/mL. The prevalent CAC was 46.2%. The multivariable adjusted odds ratio (95% confidence interval) per 1SD of LAA for CAC was 1.14 (0.96–1.36) for all participants. After stratification by age, multivariable adjusted odds ratios per 1SD of LAA were 1.34 (1.02–1.76) and 0.97 (0.77–1.23) in men aged <65 and ≥ 65 years, respectively. Conclusions: The present study showed that LAA was associated with CAC independent of HDL-C or HDL-P in middle-aged Japanese men. This finding suggests that LAA might be an early marker for CVD events. Future longitudinal studies are warranted. Graphical abstract: Image 1 Highlights: We measured LOX-1 ligand containing apolipoprotein AI (LAA) as a novel marker of dysfunctional HDL in Japanese men. LAA was positively associated with coronary artery calcification independent of HDL-C levels in middle-aged men. This finding suggests that LAA might be an early marker for cardiovascular disease.